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KMID : 0380620180500040444
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 4 p.444 ~ p.450
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Effect of bee pollen extract on activation of dendritic cells and induction of Th1 immune response
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Cho Eun-Ji
Kim Yi-Eun
Byun Eui-Hong
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Abstract
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Dendritic cells (DCs) are potent antigen-presenting cells that play a pivotal role in modulating both innate and adaptive immunity. This study examined the immunomodulatory activities of hot-water extracts of bee pollen (BPW) in bone-marrow derived DCs (BMDC) and mice splenocytes. BMDCs isolated from mice were treated with 250 and 500 μg/mL BPW for 24 h. BPW, up to 500 μg/mL, did not display any cellular toxicity against BMDCs. In fact, it functionally induced BMDC activation via augmentation of CD80, CD86, and major histocompatibility complex (MHC) class I/II expression and pro-inflammatory cytokine (tumor necrosis factor; TNF-α, interleukin; IL-6, and IL-1β) production. Interestingly, BPW treatment significantly increased the production of interferon (IFN)-γ in splenocytes, suggesting its possible contribution to Th1 polarization in immune response. Taken together, these findings suggest that BPW may regulate innate and adaptive immunity via DC activation and Th1 polarization in immune responses.
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KEYWORD
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bee pollen, dendritic cells, splenocyte, immunomodulatory activity, cytokine production
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